药理学博士,中医药健康学院专任教师。从事中药及化学合成药物抗肿瘤、抗骨质疏松和抗病毒的活性与机制研究。博士毕业于南方医科大学药学院,荣获博士一等学业奖学金、中国药理学会抗炎免疫药理委员会青年优秀论文三等奖、广东省药理学会青年优秀论文三等奖。主持国家自然青年科学基金项目1项、参与省部及以上项目两项。近五年公开发表学术论文11篇,其中以第一作者发表SCI论文6篇,中科院小类1区5篇,中文核心论文3篇,申请发明专利1项。
研究
从事中药及化学合成药物抗肿瘤、抗骨质疏松和抗病毒的活性与机制研究。
出版物
1. Integration of network pharmacology with experimental validation to reveal the mechanism of action of Longdan Xiegan Decoction against HSV2 infection and determine its effective components. J Ethnopharmacol. 2024 May: 325:117861.(小类1区,IF: 5.4)一作
2. Identification of phytochemicals in Qingfei Paidu decoction for the treatment of coronavirus disease 2019 by targeting the virus-host interactome. Biomed Pharmacother. 2022 Dec: 156:113946.(小类1区,IF: 7.419)一作
3. A011, a novel small-molecule ligand of σ2 receptor, potently suppresses breast cancer progression via endoplasmic reticulum stress and autophagy. Biomed Pharmacother. 2022 Aug:152:113232.(小类1区,IF: 7.419)一作
4. Prediction of the mechanisms of Xiaoai Jiedu Recipe in the treatment of breast cancer: A comprehensive approach study with experimental validation. J Ethnopharmacol. 2020 Apr 24:252:112603(小类1区,IF: 5.4 )一作
5. Network pharmacology combined with bioinformatics to investigate the mechanism of Xianlinggubao capsule in the treatment of osteoporosis. Phytomedicine Plus. 2021 1(3):100049. 一作
6. Synthesis, binding, and functional properties of tetrahydroisoquinolino-2-alkyl phenones as selective σ(2)R /TMEM97 ligands. Eur J Med Chem. 2021 Jan 1:209:112906.(大类1区、IF: 7.08)共一第二
7. Predicting and Exploring the Mechanisms of Erzhi Pill in Prevention and Treatment of Osteoporosis Based on Network Pharmacology and Zebrafish Experiments. DrugDes Devel Ther. 2021 Feb 24:15:817-827. (小类2区,IF: 4.8)共一第二
8. 四氢异喹啉类新化合物SYT-1抑制肿瘤细胞增殖的机制。药学学报. 2021; 56(01): 217-23. (北大核心)一作
9. 基于网络药理学探讨丹参治疗骨质疏松症的作用机制。中医学报. 2020; 35(04): 853-8. (科技核心)一作
专利
2,4,7-三取代嘧啶并吲哚化合物抗肿瘤作用、ZL201911189046.1,发明专利、排名第三